CYSTIC FIBROSIS

The research has shown that the main problem in cystic fibrosis is poor utilization of the chloride ion.  However, no one seems to have followed through to find the effect of the poor utilization of chloride.

The effect of poor utilization of chloride is a flawed metabolism of the fat soluble vitamins: A,D,E, and K. 

Vitamin A is important for the normal healthy development of the lungs.  The flawed metabolism of vitamin A results in lung damage and mucus in the lungs.  Beta carotene is the precursor of vitamin A.  It is converted into vitamin A in the liver.  Then the vitamin A has to be properly metabolized.  Beta carotene does not solve the problem.

Vitamin D is required for proper development of the nervous system.  The flawed metabolism of vitamin D results in peripheral neuropathy. 

Vitamin E seems to be important for a feeling of well being.  The flawed metabolism of vitamin results in depression.

Vitamin K is required for normal blood clotting.  The flawed metabolism of vitamin K results in bleeding.

How does one deal with these problems?  First, no supplements of the fat soluble vitamins or of beta carotene should be taken.  The diet needs to be restricted in these vitamins.  Only the amount that can be properly metabolized should be given in the diet.  That would vary in individuals.  Pancreatic enzyme supplements do improve absorption of the vitamins.  Magnesium is also critical for the metabolism of vitamin D.  Magnesium is probably one of the most critical minerals of all.  For treatment of bleeding, possibly intravenous chloride would be required: potassium chloride, magnesium chloride, even sodium chloride.  No vitamin K should be given.